Most of the research in the field of hypersomnias is devoted to narcolepsy type 1 (NT1) this project focused on idiopathic hypersomnia (IH) ( 3). Therefore, advances in understanding the disease's pathophysiology and therapeutic approaches are eagerly awaited. From the patient's point of view, it is a disorder with a significant impact on quality of life, and from society's point of view, sleep-wake disorders are a significant and, according to current research, an ever-increasing source of costs ( 2). The as-yet unresolved etiology and frequent resistance to therapeutic interventions pose a challenge for both groups ( 1). Hypersomnias of central origin are of interest to clinicians and research groups for many reasons. Further research is needed to understand the dynamics of idiopathic hypersomnia in greater detail to better understand the causes and design therapeutic approaches to improve patients' quality of life. Therapeutic focus on the parameters identified by the model should enhance the patients' subjective experience throughout illness duration and might even turn the progress from negative into positive. Although its contribution to the dynamics looks marginal at first sight, it significantly influences the contribution of other variables to the overall patient experience of the disease.Ĭonclusion: Even the simplified dynamic structure designed by the research team reflects the real-life events in patients with IH at the acceptable level of 76.1% and suggests that a similar structure plays an important role in the course of the disease. The influence of medication has been studied in detail. Psychiatric disorders influence the overall pattern at a surprisingly low level. These included sleep inertia, the refreshing potential of naps, the quality of nocturnal sleep, and the social aspects of the patient's life. The simulation results also identified the parameters that contribute the most to patients' subjective experience. Results: The overall raw data and simulation-based patterns fit at 76.1%.
IDEOPATHIC HUPERSOMNIA HYPNOGRAM SOFTWARE
The data were digitized and imported into statistical software (SPSS by IBM), and dynamic simulation software (Vensim by Ventana Systems Inc.) was used to build a causal loop diagram and stocks and flows diagram as a simulation structure. The interview covered neurologic, psychiatric, and internal medicine anamnesis, medication past and current, substance abuse, work impairment, detailed sleep-related data, specific sleep medication, and a full-length set of questionnaires including depression, quality of life, sleepiness, anxiety, fatigue, insomnia, and sleep inertia. Material and Methods: Forty-three IH patients of both sexes (female 60.5%, male 39.5%) were assessed using a detailed structured examination. This research project was designed to explain subjective experience in idiopathic hypersomnia (IH) patients influenced by their clinical symptoms and comorbidities. 4Health Care Facility, Department of the Interior, Prague, CzechiaĪims of the study: Commonly used approach to illness assessment focuses on the patient's actual state supplemented by binary records of past events and conditions.3Department of Psychiatry, Aalborg University, Aalborg, Denmark.2Department of Neurology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia.Elisabeth University, Bratislava, Slovakia Marek Susta 1 *, Karel Šonka 2, Gustav Bizik 3, Svojmil Petranek 4 and Sona Nevsimalova 2
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